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Mazdutide

Mazdutide (IBI362 / LY3305677)

GLP-1/glucagon dual receptor agonist. Weight and metabolic research.

Weight researchMetabolic researchGlycemic research
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For research use only · Not for human consumption

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1 source for 6mg·cheapest $89.99 at AMC Essentials·$15.00/mg
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AMC EssentialsBEST
★ 4.6
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Welli Labs
10mg · USA · Card
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  • ✓COAs provided — Per-batch
  • ✓Best $/mg in stock right now
  • ✓4.6★ community rating
$79.99
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AMC Essentials
6mg · $15.00/mg
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/ research index

The research base

Research Maturity
★★★★☆
4/5 — Volume of studies
Evidence Strength
★★★★☆
4/5 — Quality of evidence

Phase 3 dual GLP-1/glucagon agonist showing strong weight reduction and metabolic improvements in trials.

/ mechanism of action

How it works

Dual agonist at GLP-1 and glucagon receptors. Combines appetite suppression with increased energy expenditure via glucagon signaling.

/ research dosing

Common research protocols

Range
3 → 4.5 → 6 → 9 mg/week (titration ladder)
Frequency
Once weekly subcutaneous
Route
Subcutaneous
Cycle
Titrate up over 4-week steps; long-run protocol
Research notes

Phase 2/3 trials used escalating doses to 9mg. Start low and titrate to minimize GI effects. Dual glucagon action increases energy expenditure relative to pure GLP-1 agonists.

References
PMID: 36254416 →ClinicalTrials.gov NCT04904913
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use

As a solo compound

Standalone use is standard for metabolic research. Requires careful titration.

Common pairings
+ Cagrilintide
/ side effects

What to know

GI effects (nausea, reduced appetite) most common, dose-dependent. Titration reduces severity.

/ timeline

Realistic expectations

Titrate over weeks; effects build over months

FOR RESEARCH USE ONLY. Mazdutide is intended for laboratory research and not for human consumption.