PeptideSmart
← All compounds
peptide2 listings

PE-22-28

TREK-1 channel modulator peptide. Mood and neuroplasticity research.

Mood researchNeuroplasticity researchNeurogenesis research
Best Price
at AMC Essentials
$47.99
$6.00/mg · 8mg
Buy at AMC Essentials
/ compare by size

Every source for PE-22-28

Size:
2 sources for 8mg·cheapest $47.99 at AMC Essentials·$6.00/mg
#1
AMC EssentialsBEST
4.6
$47.99
$6.00/mg
Buy at AMC Essentials →
#2
Atomik Labz
4.7
$60.00
$7.50/mg
Buy at Atomik Labz →
/ research index

The research base

Research Maturity
★★☆☆☆
2/5 — Volume of studies
Evidence Strength
★★☆☆☆
2/5 — Quality of evidence

Spadin-derived peptide studied for rapid antidepressant-like effects via TREK-1 channel blockade.

/ mechanism of action

How it works

Blocks TREK-1 potassium channels, a mechanism linked to rapid antidepressant effects and neurogenesis in preclinical models.

/ research dosing

Common research protocols

Range
Research-stage (preclinical mcg-range dosing)
Frequency
Protocol-dependent
Route
Subcutaneous (research)
Cycle
Short research courses
Research notes

Derived from spadin. Preclinical interest for fast-acting antidepressant mechanisms via TREK-1. Human dosing not established.

FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use

As a solo compound

Standalone neuro research.

Common pairings
/ side effects

What to know

Limited human data; preclinical tolerability favorable.

/ timeline

Realistic expectations

Days to weeks (preclinical)

/ recommendation

Where to buy PE-22-28

🏆Our pick for PE-22-28
AMC Essentials
8mg · USA · Card
  • Third-party tested (Verified)
  • COAs provided — Per-batch
  • Best $/mg in stock right now
  • 4.6★ community rating
Also solid
Atomik Labz
8mg · $7.50/mg
$60.00
Buy →
FOR RESEARCH USE ONLY. PE-22-28 is intended for laboratory research and not for human consumption.