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PE-22-28

TREK-1 channel modulator peptide. Mood and neuroplasticity research.

Mood researchNeuroplasticity researchNeurogenesis research
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For research use only · Not for human consumption

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Every source for PE-22-28

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1 source for 5mg·cheapest $49.99 at Welli Labs·$10.00/mg
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Welli LabsBEST
★ 4.6
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🏆Our pick for PE-22-28
AMC Essentials
8mg · USA · Card
  • ✓Third-party tested (Verified)
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  • ✓4.6★ community rating
$47.99
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Atomik Labz
8mg · $7.50/mg
$60.00
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Welli Labs
5mg · $10.00/mg
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/ research index

The research base

Research Maturity
★★☆☆☆
2/5 — Volume of studies
Evidence Strength
★★☆☆☆
2/5 — Quality of evidence

Spadin-derived peptide studied for rapid antidepressant-like effects via TREK-1 channel blockade.

/ mechanism of action

How it works

Blocks TREK-1 potassium channels, a mechanism linked to rapid antidepressant effects and neurogenesis in preclinical models.

/ research dosing

Common research protocols

Range
Research-stage (preclinical mcg-range dosing)
Frequency
Protocol-dependent
Route
Subcutaneous (research)
Cycle
Short research courses
Research notes

Derived from spadin. Preclinical interest for fast-acting antidepressant mechanisms via TREK-1. Human dosing not established.

References
PMID: 25116097 →
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use

As a solo compound

Standalone neuro research.

Common pairings
+ Semax+ Selank
/ side effects

What to know

Limited human data; preclinical tolerability favorable.

/ timeline

Realistic expectations

Days to weeks (preclinical)

FOR RESEARCH USE ONLY. PE-22-28 is intended for laboratory research and not for human consumption.