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/ comparison

CJC-1295
vs
Sermorelin

Side-by-side comparison of mechanism, research, dosing, side effects, and pricing.

peptide

CJC-1295

Synthetic GHRH analog. Stimulates natural GH release.

Cheapest
$33.11
5mg at Nano Blue Labs
See CJC-1295 →
peptide

Sermorelin

Original GHRH analog. The 'father' of growth hormone secretagogues.

Cheapest
$30.30
10mg at Biocase Innovations
See Sermorelin →
/ research scoring

Research base

CJC-1295
Research Maturity★★★★☆
Evidence Strength★★★★☆

60+ studies. Solid evidence for GH stimulation. Works synergistically with GHRP compounds.

Sermorelin
Research Maturity★★★★☆
Evidence Strength★★★★☆

Decades of research. Well-established safety profile.

/ mechanism

How they work

CJC-1295

GHRH receptor agonist. Stimulates anterior pituitary to release GH.

Sermorelin

GHRH receptor agonist. Shorter half-life than CJC-1295.

/ research dosing

Protocols compared

CJC-1295
Range: No DAC: 100-300 mcg/dose, daily; DAC: 1-2 mg/week
Frequency: No DAC: daily before bed (5 on/2 off); DAC: weekly
Route: Subcutaneous on empty stomach
CJC-1295 (no DAC, also called Mod-GRF 1-29) has 30-min half-life — daily dosing maintains pulsatile GH release. CJC-1295 DAC has 6-8 day half-life — sustained but less physiological. No DAC version typically preferred for research due to better pulse pattern. Often stacked with Ipamorelin 1:1.
Sermorelin
Range: 100-500 mcg/day (most common: 200-300 mcg/day)
Frequency: Once daily before bed
Route: Subcutaneous
Shortest GHRH analog (29 amino acids, 10-20 min half-life). Daily bedtime dosing essential due to short duration. Can elevate cortisol/prolactin slightly. Often paired with GHRP for amplified GH pulse.
/ side effects & timeline

What to expect

CJC-1295
Side effects

Minimal. Occasional flushing at injection site.

Timeline

GH elevation 1-2 weeks

Sermorelin
Side effects

Minimal. Occasional injection site reaction.

Timeline

4-8 weeks

/ pricing

Price comparison

CJC-1295
Lowest price$33.11 (5mg)
Min $/mg$4.09/mg
Avg $/mg$8.17/mg
Max $/mg$13.60/mg
Sermorelin
Lowest price$30.30 (10mg)
Min $/mg$3.03/mg
Avg $/mg$6.79/mg
Max $/mg$12.49/mg
/ which to pick

The honest verdict

Pick CJC-1295 if: Effective standalone for GH research.

Pick Sermorelin if: Reliable standalone option with extensive research history.

Why not both? Some researchers run them together. Check our Interaction Matrix to see if these compounds synergize or work independently.

FOR RESEARCH USE ONLY. Both compounds are intended for laboratory research and not for human consumption.