Skin & Hair Research Protocol
Collagen synthesis + tissue repair
GHK-Cu is the most-studied peptide for collagen and skin research. Combined with BPC-157 for systemic repair signaling.
How this works
GHK-Cu directly upregulates collagen I, III, and IV synthesis, increases TGF-β signaling, and inhibits MMPs (which break down collagen). BPC-157 provides systemic tissue repair signaling and angiogenesis support.
The synergy
GHK-Cu can be used topically (skin) or subQ (systemic). Adding BPC-157 enhances the repair environment by upregulating growth factors throughout the body. Hair follicle research suggests both contribute via different mechanisms.
How researchers run it
Each compound, explained
GHK-Cu
Natural copper complex first isolated in 1973. Extensively studied for skin, hair, and collagen applications.
Upregulates collagen I, III, IV synthesis. Inhibits matrix metalloproteinase (MMP). Promotes tissue remodeling.
Topical: minimal. Systemic: occasional mild blue discoloration at injection site.
BPC-157
Pentadecapeptide derived from gastric juice protein. Extensively researched for tissue repair.
Upregulates HGF (hepatocyte growth factor) and FGF signaling. Increases fibroblast proliferation and migration. Promotes angiogenesis.
Generally well-tolerated. Rare reports of mild GI discomfort at high doses.